Versamune® Platform

The Versamune® Platform Activates all Critical Mechanisms of Cancer Immunotherapy

In human clinical trials, Versamune®’s excellent safety profile, first observed in toxicology studies, was corroborated with no significant toxicities observed at any dose. Versamune®’s high level of antigen-specific T-cell responses was also corroborated in human clinical studies. The combination of Versamune®’s human efficacy and excellent safety profile is an important step toward the development of next generation therapies to treat both early- and late-stage cancers. It also suggests that Versamune®-based products will be uniquely suited for use in combination with other immuno-oncology platforms to develop powerful therapies.

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Antigen Uptake by Dendritic Cells and Access to MHC Class I and II Pathways Immune Activation Reduction of Immune Suppressor Cells
The platform is designed, and has been demonstrated, to overcome the critical obstacle of antigen uptake, processing and entry into the cytoplasm.

Versamune® has been shown to activate the immune system via the MAP Kinase signaling pathway.

Critical chemokines are locally induced specifically in the lymphatics.

This is believed to contribute toward the high activation and proliferation of killer (CD8+) T-cells without the inflammatory toxicities associated with cytokines and adjuvant administration.

In preclinical studies, subcutaneous administration of Versamune® was associated with significant reduction in both the regulatory T-cell (Treg) and myeloid derived suppressor cell (MDSC) populations.

This effect is believed to be a major contributor to the observed ability in preclinical studies to overcome immune tolerance and inhibit tumor growth in all aggressive tumor models investigated.

In human clinical trials, the high safety profile observed in toxicology studies has been corroborated with no significant toxicities observed at any dose.  The high level of antigen-specific T-cell responses has also been corroborated in human clinical studies.

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    PDS Biotechnology is a clinical stage biopharmaceutical company developing novel cancer immunotherapies and vaccines for infectious diseases.

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    PDS Biotechnology Corporation
    Commercialization Center for Innovative Technologies (CCIT)

    675 US Highway One
    North Brunswick, NJ 08902

    Tel: 732-640-0145
    Fax: 732-640-0144