PDS0202 neutralized multiple strains of influenza and provided protection against infection in preclinical studies
FLORHAM PARK, N.J., July 14, 2022 (GLOBE NEWSWIRE) -- PDS Biotechnology Corporation (Nasdaq: PDSB), a clinical-stage immunotherapy company developing a growing pipeline of molecularly targeted cancer immunotherapies and infectious disease vaccines based on the Company’s proprietary Versamune® and Infectimune™ T cell activating technologies, today announced an upcoming poster presentation at the 41st annual meeting of the American Society of Virology meeting. The study demonstrated that the investigational universal flu vaccine was effective against multiple strains of the influenza virus.
In this preclinical study, PDS0202, in which Infectimune™ is formulated with Computationally Optimized Broadly Reactive Antigens (COBRA) influenza antigens developed by the laboratory of renowned influenza expert, Dr. Ted Ross, was evaluated for its potential ability to provide effective and broad neutralization of multiple influenza strains as well as to provide protection against infection. Highlights include:
- Animals vaccinated with PDS0202 demonstrated significantly higher antibody titers against H1 and H3 influenza strains compared to animals vaccinated without Infectimune™.
- All animals vaccinated with PDS0202 survived a lethal challenge with the H1N1 pandemic strain of influenza, compared to a ~40% survival rate in animals vaccinated with COBRA antigens only and a 0% survival rate in untreated animals.
- Infectimune™ allowed for significant dose-sparing with effective protection demonstrated using 25-fold lower doses of the COBRA antigens in animals.
- No detectable virus was found in lungs from animals treated with PDS0202, compared to the presence of high virus titers in lungs evaluated both from animals treated only with COBRA antigens and also in the untreated animals.
- The COBRA antigens elicit broadly reactive antibody responses to influenza, and Infectimune™ can promote antigen cross-presentation leading to higher immunogenicity with enhanced levels of antibody and T cell responses resulting in reduced doses of vaccine to protect against viral challenge in animals.
“We are pleased to share the potential of the novel Infectimune™ and COBRA-based investigational vaccine with the virology community,” said Lauren V. Wood, MD, Chief Medical Officer of PDS Biotech. “According to the World Health Organization, influenza is estimated to result in about 3 to 5 million cases of severe illness, and about 290,000 to 650,000 respiratory deaths globally each year. Currently, there is no universal vaccine that provides broad protection against multiple strains of influenza. As a result, the protective efficacy of the current vaccines varies widely from season to season. These data suggest that PDS0202 has the potential to achieve the goal of providing the broad protection sought in a universal influenza vaccine.”
“The preclinical results show the potential of PDS0202 to be effective in preventing viral invasion of the lungs by multiple strains of the influenza virus,” stated Ted Ross, Ph.D., Professor, and Director of the Center for Vaccines and Immunology, University of Georgia. “The demonstration of a well characterized and robust immune response to the COBRA antigens suggests potential for broad and long-term protection against multiple strains of influenza.”
The preclinical PDS0202 study was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and was performed by Drs. Jerold Woodward at the University of Kentucky College of Medicine and Ted Ross at the University of Georgia. Dr. Ted Ross is Principal Investigator at the NIAID Collaborative Influenza Vaccine Innovation Center (CIVICs) located at the University of Georgia. PDS Biotech has licensed the COBRA antigens from the University of Georgia to develop PDS0202.
Abstract Number: 3733830
Program Number: P9-19
Abstract Title: Infectimune™ enhances antibodies elicited by COBRA hemagglutinin influenza vaccine
Presenting Author: Hua Shi, Center for Vaccines and Immunology, University of Georgia
Session: P9: Orthomyxoviruses
Date and Time: Sunday, July 17, 2022; 8:30 PM to 10:00 PM EDT
Location: Exhibit Hall B
About PDS Biotechnology
PDS Biotech is a clinical-stage immunotherapy company developing a growing pipeline of molecularly targeted cancer and infectious disease immunotherapies based on the Company’s proprietary Versamune® and Infectimune™ T cell activating technology platforms. We believe our Versamune®-based products have demonstrated the potential to overcome the limitations of current immunotherapy by inducing in vivo, large quantities of high-quality, highly potent polyfunctional tumor specific CD4+ helper and CD8+ killer T cells. PDS Biotech has developed multiple therapies, based on combinations of Versamune® and disease-specific antigens, designed to train the immune system to better recognize diseased cells and effectively attack and destroy them. The Company continues to advance its pipeline of preclinical and clinical candidates to address a wide range of cancers including HPV16-associated cancers (anal, cervical, head and neck, penile, vaginal, vulvar) and breast, colon, lung, prostate and ovarian cancers.
Our Infectimune™ -based vaccines have demonstrated the potential to induce not only robust and durable neutralizing antibody responses, but also powerful T cell responses including long-lasting memory T cell responses. To learn more, please visit www.pdsbiotech.com or follow us on Twitter at @PDSBiotech.
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